ESPERIENZE PROFESSIONALI

1. Dal 2000 to 2002 Scuola di Medicina e Chirurgia “Federico II” di Napoli Dip. Di medicina Clinica e Sperimentale
Brsa di ricerca per il progetto dal titolo:
The role of HOX genes in cancer and metabolic disease.

2. Dal 2002 al 2005 Scuola di Medicina e Chirurgia “Federico II” Naples Dip. Di Fisiologia:
Ph.D Fellow titolo del progetto:
The relationship between adipocyte biology and molecular markers of inflammation (IL6, CRP, Fetuin-B).

3. Dal 2005 al 2008 Scuola di Medicina e Chirurgia “Federico II” Dip di Patologia Sistemtica
Postdoc Fellow titolo del progetto:
Analisi del comportamento di Epatociti umani cresiucti in un bioreattore trattati con agenti chimici farmacologici. Il progetto è stato finanziato con un grant FIRB in collaborazione con Prof. Emanuele Drioli del NR di Rende (Cosenza) e con il Prof. Roberto D'Agostino Direttore della Scuola di Chimica dell’Università di Bari.

4. Dal 2008 al 2010 Scuola di Medicina e Chirurgia “Federico II” Dip. Di Nefrologia.
Borsa di ricerca titolo del progetto:
Ruolo dell’IL-6 e dei suoi recettori (gp80 e gp130) nella patologia renale.

5. Dal 2010 al 2013 Scuola di Medicina e Chirurgia “Federico II” Dip. Di Medicina Clinica e Seprimentale.
Borsa di ricerca titolo del progetto:
The deregulation of lncRNA HOTTIP and HOXA13 genes expression, in human hepatocarcinoma.

6. Dal 2013 al 2016 Scuola di Medicina e Chirurgia “Federico II” Naples Dip. Di Neuroscienze, Scienze della Riproduzione ed Odontostomatologiche
Ph.D fellow titolo del progetto:
The resin monomers can lead the deregulation of lncRNA HOTTAIR in Human Gingival Fibroblasts.

7. Dal 2016 al 2018
Scuola di Medicina e Chirurgia “Federico II” Naples Dip. Di Neuroscienze, Scienze della Riproduzione ed Odontostomatologiche
Assegno di ricerca titolo del progetto:
The role of HOX network as epigenetic model during human bone
development

8. Dal 2019 al 2020
Dipartimento di Farmacia dell’Università di Fisciano
Borsa di Studio titolo del progetto:
Study of new anticancer molecules in the control of HOX genes in human breast cancer

9. Dal 2020-2022
Rudger Boskovicu Institute di Zagabria (Coazia). Ricercatore.
Deregulation of HOX genes during neoplastic transformation.

TITOLI DI STUDIO

1990/’91
Diploma di Scuola media Superiore di Tecnico di laboratorio Chimico-Biologico conseguito presso l’Istituto IPSIA "G.Caselli" di Napoli con punteggio di 50/50

2001/’02
Laurea in Scienze Biologiche conseguito presso l’ Università degli Studi di Napoli Federico II Facoltà di Scienze, con punteggio di 110/110 con lode

2005/’08
Ph.D in Scienze dell’Alimentazione Umana ’ Università degli Studi di Napoli Federico II Facoltà di Scienze, valutazione Eccellente.

2012-2015
Ph.D in Medicina Clnica e Sperimentale’ conseguito presso l’ Università degli Studi di Napoli Federico II valutazione Eccellente.

COLLABORAZIONI INTERNAZIONALI:

1. 2011-2014
Prof. L. Terracciano responsabile della Divizione di Patologia Molecolare dell’University of Basel Medical School.
Progetto: The deregulation of lncRNA HOTTIP and HOXA13 genes expression, in human hepatocarcinoma.

2. 2011-2015
Prof. I. Martin, responsabile del Dipartimento di Biomedicina dell’ University Hospital Basel.
Progetto: To identify HOXC4 and HOXD8 genes as discriminants markers between nasal and articular cartilage.

3. 2015-2018
Prof. J. Syed, Responsabile de Dip di Odontostomatologia del King Abdul Aziz University. Progetto: Characterize new markers during Osteoblasts differentiation

PUBBLICAZIONI

1.European Journal of Cancer: Cantile M, Procino A, D’Arminento M, Cindolo L, CilloC. IN VIVO EXPRESSION OF THE WHOLE HOX GENE NETWORK IN HUMAN BREAST CANCER. 2003 Jan; 39 (2): 257-64
2.Journal of cellular Physiology:Cantile M, Pettinato G, Procino A, Feliciello I, Cindolo L, Cillo C.THE HOX GENE NETWORK IS INVOLVED IN THE TRASCRIPTIONAL REGULATION OF IN VIVO HUMAN ADIPOGENESIS. 2003 Feb; 194 (2): 225-36

3.Semin. Nephrology. Memoli B, Romano G, D’Arcangelo R, DelPrete M, Esposito P, Procino A, Cuomo V, Bisesti V, Capuano A, Andreucci MV. THE ROLE OF INTERLEUKIN-6 AND OF ITS SOLUBLE RECEPTORS IN THE BIOPCOMPATIBILITY OF DIALYIS TREATAMENT. 2004 Sept; 24(5): 492-4
4.Giornale Italiano di Nefrologia. Memoli B, Grandaliano G, Soccio M, Procino A, Pertosa G. THE IL-6 SOLUBLE RECEPTORS IN HEMODIALYZED PATIENTS. 2004 Dec; S-30:S117-121
5.J Am Soc Nephrol. Memoli B, Grandaliano G, Soccio M, Pstiglione L, Guida B, Bisesti V, Espsito P, Procino A, Marrone D, Michael A, Andreucci M, Schena FP, Pertosa G. IN VIVO MODULATION OF SOLUBLE “ANTAGONISTIC” IL-6 RECEPTOR (sgp130) IN PATIENTS UNDERGOING HEMODIALYSIS TREATMENT. 2005 Apr; 16 (4):1099-107.

6.Kidney Int. Guida B, Laccetti R, Trio R, Procino A, Romano G, Memoli B. BODY MASS INDEX AND SURVIVAL DIFFERENCES IN DIALYSIS PATIENTS. 2005 Apr; 67 (4):1637
7.Biomaterials. De Bartoli L, Salerno S, Morelli S, Giorno L, Rende M, Memoli B, Procino A, Andreucci VE, Bader A, Drioli Drioli E. LONG-TERM MAINTENANCE OF HUMAN EPATOCYTES IN OXYGEN-PERMEABLE MEMBRANE BIOREACTOR. 2006 Sep; 27 (27):4794-803
8.Biochem Pharmacol: Andreucci M, Fuiano G, Presta P, Esposito P, Faga T, Bisesti V, Procino A, Altieri V, Tozzo C, Memoli B, Michael A. RADIOCONTRAST MEDIA CAUSE DEPHOSPHORYLATION OF AKT AND DOWNSTREAM SIGNALING TARGETS IN HUMAN RENAL PROXIMAL TUBULAR CELLS. 2006 Nov 15; 72 (10):1334-42
9.AJP Endocrinology and Metabolism: Memoli B, Procina A, Calabrò P,Esposito P, grandaliano G, Pertosa G, Prete MD, Andreucci M, Lillo SD, Ferulano G, Cillo C, Savastano S, Colao A, Guida B. INFLAMMATION MAY MODULATE INTERLEUKIN 6 AND C-REACTIVE PROTEIN GENE EXPRESSION IN THE ADIPOSE TISSUE: THE ROLE OF IL-6 CELL MEMBRANE RECEPTOR 2007 OCT; 293(4):E1030-5
10.Journal of Membrane Science: Morelli S, Salerno S, Rende M, Lopez L, Favia P,Procino A, Memoli B, Andreucci VE, d’Agostino R, Drioli E, De Bartoli L. HUMAN EPATOCYTES FUNCTIONS IN A GALACTOSYLATED MEMBRANE BIOREACTOR. 2007 Jun; 302:27-35
11.Biomaterials: Memoli B, De Bartoli L, Favia P, Morelli S, Lopez L, Procino A, Barbieri G, Curcio E, Giorno L, Esposito P, Cozzolino M, Brancaccio D, Andreucci VE,d’Agostino R, Drioli E. “FETUIN-A GENE EXPRESSION, SYINTHESIS AND RELASE IN PRIMARY HUMAN HEPATOCYTES CULTURED IN GALACTOSYLATED MEMBRANE BIOREACTOR”. 2007 Nov; 28 (32):4836-44
12. Am J Med. Guida B, Laccetti R, Procino A, Memoli B. “OBESITY PARADOX” OR A BETTER NUTRITIONAL STATUS? 2008 Jul; 121 (7)e7 author reply e9.

13. Am J Kidney Disease Pertosa G, Siomne S, Ciccone M, Porreca S, Zazza G, Dalfino G, Memoli B, Procino A, Bonomini M, Sirolli V, Castellano G, Gesualdo G, Ktena L, Schena FP, Grandaliano G. SERUM FETUIN A IN HEMODIALYSIS: A LINK BETWEEN DERANGEMENT OF CALCIUM-PHOSPHORUS HOMEOSTASIS AND PROGRESSION OF ATHEROSCLEROSIS? 2009 Jan 22 Mar; 3 (3):467-74

14. Lupus Esposito P, Balletta MM, Procino A, Postiglione L, Memoli B. INTERLEUKIN-6 RELEASE FROM PERIPHERAL MONONUCLEAR CELLS IS ASSOCIATED TO DISEASE ACTIVITY AND TREATMENT RESPONSE IN PATIENTS WITH LUPUS NEPHRITIS 2009 Dec; 18 (14):1329-30

15. Clin Sci (Lond) Memoli B, Salerno S, Procino A, Postiglione L, Morelli S, Sirico ML, Giordano S, Ricciardone M, Drioli E, Andreucci VE, De Bartoli L. TRANSLATIONAL APPROACH TO MICRO-INFLAMMATION IN END STAGE RENAL DISEASE: MOLECULAR EFFECTS OF LOW LEVELS OF INTERLEUKIN 6. 2010 MAY 14;119 (4):163-74

16. Anti-Cancer Drugs Cantile M, Schiavo G, Renato F, Cindolo L, Procino A, D’Armiento M, Facchini G, Terracciano L, Botti G, Cillo C. THE EXPRESSION THE LUMBO-SACRAL HOX GENE, CRUCIAL IN KIDNEY ORGANOGENESIS, IS SYSTEMATICALLY DEREGULATED IN CLEAR CELL KIDNEY CANCERS. 2011 Jun; 22(5).392-401

17. Journal of Cellular Biochemistry. Schiavo G, D’Antò V, Cantile M, Procino A, Di Giovanni S, Valletta R, Terracciano L, Baumhoer D, Jundt G, and Cillo C. DEREGULATED HOX GENES IN AMELOBLASTOMAS ARE LOCATED IN PHYSICAL CONTIGUITY TO KERATIN GENES. 2011 Jul 5. doi: 10.1002/jcb 23248

18. Current Medicinal Chemistry Cantile M, Franco R, Schiavo G, Procino A, Cindolo L, Botti G and Cillo C.THE HOX GENE NETWORK IN UROGENITAL CANCERS: MECHANISM AND POTENTIALS THERAPEUTIC IMPLICATION. 2011 NOV NOV 1;18 (32):4872-84

19. Mediators of inflammation Sirico ML, Guida B, Procino A,Pota A,Sodo M,Grandaliano G,Simone S,Pertosa G,Riccio E, and Memoli B. HUMAN MATUREADIPOCYTES EXPRESS ALBUMIN AND THIS EXPRESSION IS NOT REGULATED BY INFLAMMATION 2012:236796.

20. Cell Biol Int. Procino A, Cillo C. THE HOX GENES NETWORK IN METABOLIC DISEASES. 2013 Cell Biol Int. 2013 Nov;37(11):1145-8.

21. Biomed Res Int. Servillo G, Vargas M, Pastore A, Procino A, Iannuzzi M, Capuano A, Memoli A, Riccio E, Memoli B. IMMUNOMODULATORY EFFECT OF CONTINUOUS VENOVENOUS HEMOFILTRATION DURING SEPSIS: PRELIMINARY DATA. 2013; 2013:108951. doi: 10.1155/2013/108951. Epub 2013 Jul 23.

22. Hepatology Quagliata L, Matthias S.M, Piscuoglio S, Arabi L, Ruiz C, Procino A, Kovac M, Moretti F, Makowska S, Boldanova T, Anderson J.B, Hammerle M, Tornillo L, Heim M.H, Diederichs S, Cillo C and Terracciano L. LNCRNA HOTTIP/HOXA13 EXPRESSION IS ASSOCIATED WITH DISEASE PROGRESSION AND PREDICTS OUTCOME IN HEPATOCELLULAR CARCINOMA PATIENTS. 2014 Mar;59(3):911-23.

23. Cell Biology International Procino A. “OVERXPRESSION OF PROX-1 GENE IN OMENTAL ADIPOSE TISSUE AND ADIPOCYTES COMPARED WITH SUBCUTANEOUS ADIPOSE TISSUE AND ADIPOCYTES IN HEALTHY PATIENTS.” Cell Biol Int. 2014 Jul;38(7):888-91
24. Science Translational Medicine Pelttari K, Pippenger B, Feliciano S, Scotti C, Mainil-Varlet P, Procino A, Jakob M, Cillo C, Barbero A and Martin I. “ADULT HUMAN NEURAL CREST-DERIVED CELLS FOR ARTICULAR CARTILAGE REPAIR. SCI TRANSL MED. 2014 AUG 27;6(251):251RA119. DOI: 10.1126/SCITRANSLMED.3009688. Sci Transl Med. 2014 Aug 27;6(251):251ra119.

25. Journal Molecular and Gentic Medicine Procino A. “THE PARALOGOUS GROUP HOX 13 DISCRIMINATES BETWEEN NORMAL COLON TISSUE AND COLON CANCER” J Mol Genet Med 2014 Sep 30 (8):130.

26. Journal Molecular and Gentic Medicine Procino A. “HOX GENES AND ONCOGENESIS” 2014 Oct 15 (8):130

27. Clinical Oral Investigation Gandolfi MG, Spagnuolo G, Siboni F, Procino A, Rivieccio V, Prati C, Rengo S. “PROPERTIES OF EXPERIMENTAL BIPHASIC CALCIUM SILICATE/CALCIUM PHOSPHATE CEMENTS FOR DIRECT PULP CAPPING” Clin Oral Inv 2015 Nov;19(8):2075-89

28. American Journal of Nutrition and Health Procino A. “THE HOXD LOCUS IN THE PATHOGENESIS OF CELIAC DISEASE” 2015 July 09 (1):82-85

29. Int. J. Res. Stud. Sci. Eng Techn. Procino A, Simeone M, Spagnuolo G.“ROLE OF IL6 AND ITS RECEPTORS (GP80, GP130) IN TEGDMA AND HEMA CYTOTOXICITY” 2015 July 14 (2):73-76

30. American Journal Experimental Biology Procino A. “DOES CLASS I HOMEOBOX GENES IMPLICATED IN CELIAC DISEASE?” 2015 OCT 2:7-11

31. Current Signal Transcription Therapy Procino A “LNCRNA HOTAIR, HOXC11 AND HOXC12 GENE EXPRESSION ARE UPREGULATED IN CACO2 CELLS TREATED WITH P31-43 TOXIC PEPTIDE.” 2016 GEN. 11(1):33-37

32. Current Medicinal Chemstry Procino A. “CLASS I HOMEOBOX GENES, THE ROSETTA STONE OF HUMAN CELL BIOLOGY, IN THE REGULATION OF CARDIOVASCULAR DEVELOPMENT” 2016;23(3):265-75

33. Journal of Oral Science POLYACRYLIC RESINS REGULATE THE TRANSCRIPTIONAL CONTROL OF IL6 AND ITS RECEPTORS (GP80 AND GP130) IN HUMAN GINGIVAL FIBROBLASTS (HGFS) Borelli B, Zarone F, Rivieccio V, Riccitiello R, Simeone M, Sorrentino R, Rengo S, Spagnuolo S and Procino A.

35. International Journal of Biological and Chemical Sciences Procino A. “THE HOX NETWORK LEADS THE NEOPLASTIC TRANSFORMATION IN THE HUMAN SOLID TUMORS” 2016;9:8-13

36. Human Vaccine and Immunitherapeutics: Procino A. and Feliciello I. The pulmonary-proteoliposome as a new therapeutic approach for Coronaviruses.

37. Journal of Stem Cells: Procino A. and Feliciello I. The Monomeric Resins TEGDMA and HEMA Regulate the Transcriptional Control of Matrix Metalloproteinases MMP-2 and MMP-9, in Human Pulp Fibroblasts and Mesenchymal Stem Cells. 2021, pp. 153–169

38. Bahrain Medical Bulleti Novel anticancer drug 5h-pyro[3,2-a] phenoxazin-5-one (PPH) regulates lncRNA HOTAIR and HOXC genes in human MCF-7 cells Manfra, M., Feliciello, I., Bolognese, A., ...Campiglia, P., Procino, A. 2021, 43(1), pp. 334–341

39. Journal of Biological Researh mRNA vaccines: Why and how they should be modified Feliciello, I., Procino, A. this link is disabled, 2021, 94(2), pp. 82–83

40. International Journal of Molecular Sciencesthis Regulation of ssb Gene Expression in Escherichia coli Feliciello, I., Đermić, E., Malović, H., ...Procino, A., Đermić, D. 2022, 23(18), 10917

LIBRI

1. Edizioni Accademiche Italiane Procino A. “ROLE OF ADIPOSE ORGAN IN THE INFLAMMATORY PROCESS (ITALIAN LANGUAGE)”. ISBN number: 978-3-639-77259-3

2. Edizioni Accademiche Italiane Procino A. “DEREGULATION OF HOX GENE NETWORK IN HUMAN NEOPLASTIC TRANSFORMATION (ITALIAN LANGUAGE)” ISBN number: 978-3-639-77558-7

3. Edizioni Accademiche Italiane Procino A. “ROLE OF HOX GENES IN THE DEVELOPMENT OF ADIPOSE ORGAN (ITALIAN LANGUAGE)”. ISBN number: 978-3-639-77969-1

CAPITOLI DI LIBRI

1. Emerging Trends in Disease and Health Research The HOX Gens and ncRNAs Control the Pathogenesis of the Celiac Disease. Procino Alfredo. 2022 pp.66-91

2. Stem Cells in Disease Pathogenesis The monomeric resins TEGDMA and HEMA regulate the transcriptional control of matrix metalloproteinases MMP-2 and MMP-9, in human pulp fibroblasts and mesenchymal stem cells
Procino, A., Feliciello, I. 2021, pp. 153–169